Renin acts on a protein circulating in the plasma called angiotensinogen, cleaving this substance into angiotensin I.

Renin is secreted from the kidneys in response to variations in blood pressure and volume and plasma sodium and potassium levels. Production of aldosterone (in adult humans, about 20–200 micrograms per day) in the zona glomerulosa of the adrenal cortex is regulated by the renin-angiotensin system. Pathways in the biosynthesis of steroid hormonesĪldosterone is synthesized in the body from corticosterone, a steroid derived from cholesterol.

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Hormone secreted by adrenal gland